ea0065oc2.5 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019
Gualtieri Angelica
, Nicholson James
, Tan Rachael
, Jimenez Fernando
, Dattani Mehul
, Guasti Leonardo
, Gaston-Massuet Carles
Efnb2 encodes for the ligand Ephrinb2 that binds to its cognate Eph receptor, with which plays an integral role in angiogenesis, stem cell regulation and tumorigenesis. Using a pituitary-specific Cre-driver (Hesx1Cre), we conditionally deleted Efnb2 from the early stem/progenitor cells (PSCs) of the developing pituitary gland. We found that Efnb2 is expressed in PSCs both during embryogenesis and adulthood, suggesting its...